In Victorian London, a serial killer dubbed The Limehouse Golem by the press, leaves a trail of victims in his wake. The seemingly random murders span across the social with the only clue being a series of cryptic messages written in the blood of his victims. With few leads and increasing public pressure, Scotland Yard assigns the case to Inspector Kildare (Bill Nighy), a seasoned detective who has a sneaking suspicion that he's being set up to fail. Kildare career has stalled due to rumours that “he’s not the marrying type. Investigations eventually yield a list of four potential suspects.  The music hall actor Dan Leno, the author George Gissing and revolutionary Socialist Karl Marx. However, Kildare finds that the forth, John Cree, is already dead; poisoned by his wife Elizabeth (Olivia Cooke) who awaits trial for murder. Is the key to the Golem’s identity to be found through further investigation of his murders, or by solving the truth of the Cree case?