CIA specialist interrogator Alice Rancine (Noomi Rapace) is on secondment to MI5 while she nurses her guilt over a previously failed operation that left civilians dead. Her old boss Eric Lasch (Michael Douglas) thinks it’s time she returned to what she does best. Rancine then receives a request from the CIA London Station to crack a terrorist courier who can provide access to a major cell. However, it soon becomes clear that the operation has not been officially sanctioned and Rancine has been duped by rogue elements within the Agency. Alone and on the run from the CIA, MI5 and independent contractors, Alice finds an unexpected ally in ex-Marine Jack Alcott (Orlando Bloom) who she finds robbing her apartment. Together, the pair pursue the lead she obtained while interrogating the courier and attempt to stop a biological attack from happening on UK soil.